The Mid-South Conference was formed in 1995 to serve as the competitive base for the institution’s athletic programs. The move effectively merged the athletic pursuits of similar institutions. The conference is unique in its broad-based athletic competition for men and women, offering championships in 29 sports.

The presidents of each institution serve on the Board of Directors which directly oversees the conference and the office of the commissioner. This administrative "hands-on" role of each school's president is unique among athletic conferences and ensures a proper balance in the academic pursuits of student-athletes.

True to its commitment to broad-based athletic competition, the Mid-South Conference recognizes the value of extensive campus-based sports programs that maximize the opportunities for athletic competition among their students.

The Mid-South Conference has enjoyed a prosperous growth since its inception with eight charter members in 1995. Seven full members and 18 affiliate members now call the Mid-South Conference home. The full members include Bethel University, Campbellsville University, Cumberland University, University of the Cumberlands, Freed-Hardeman University, Georgetown College, and Lindsey Wilson College.

On the field, the Mid-South Conference’s rich championship tradition includes 34 NAIA National Championships. Off the field, the MSC celebrates its student-athletes’ accomplishments in the classroom and within their community with its Champions of Character initiative.

The Mid-South Conference office is located in Bowling Green, Kentucky.